Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins

Aggregates of the neuronal Tau protein are found inside neurons of Alzheimer's disease patients. Development of the disease is accompanied by increased, abnormal phosphorylation of Tau. In the course of the molecular investigation of Tau functions and dysfunctions in the disease, nuclear magnet...

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Dettagli Bibliografici
Pubblicato in:J Vis Exp
Autori principali: Danis, Clément, Despres, Clément, Bessa, Luiza M., Malki, Idir, Merzougui, Hamida, Huvent, Isabelle, Qi, Haoling, Lippens, Guy, Cantrelle, François-Xavier, Schneider, Robert, Hanoulle, Xavier, Smet-Nocca, Caroline, Landrieu, Isabelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: MyJove Corporation 2016
Soggetti:
Biochemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226463/
https://ncbi.nlm.nih.gov/pubmed/28060278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/55001
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