Identification of the Tau phosphorylation pattern that drives its aggregation

Determining the functional relationship between Tau phosphorylation and aggregation has proven a challenge owing to the multiple potential phosphorylation sites and their clustering in the Tau sequence. We use here in vitro kinase assays combined with NMR spectroscopy as an analytical tool to genera...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Despres, Clément, Byrne, Cillian, Qi, Haoling, Cantrelle, François-Xavier, Huvent, Isabelle, Chambraud, Béatrice, Baulieu, Etienne-Emile, Jacquot, Yves, Landrieu, Isabelle, Lippens, Guy, Smet-Nocca, Caroline
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576827/
https://ncbi.nlm.nih.gov/pubmed/28784767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708448114
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