Identification of the Tau phosphorylation pattern that drives its aggregation

Determining the functional relationship between Tau phosphorylation and aggregation has proven a challenge owing to the multiple potential phosphorylation sites and their clustering in the Tau sequence. We use here in vitro kinase assays combined with NMR spectroscopy as an analytical tool to genera...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Despres, Clément, Byrne, Cillian, Qi, Haoling, Cantrelle, François-Xavier, Huvent, Isabelle, Chambraud, Béatrice, Baulieu, Etienne-Emile, Jacquot, Yves, Landrieu, Isabelle, Lippens, Guy, Smet-Nocca, Caroline
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576827/
https://ncbi.nlm.nih.gov/pubmed/28784767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708448114
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