Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble intraneuronal fibrils within Alzheimer’s disease (AD) brains. In recent years, other posttranslational modifications (PTMs) have been highlighted...

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Publicado en:Front Mol Neurosci
Autores principales: Cantrelle, François-Xavier, Loyens, Anne, Trivelli, Xavier, Reimann, Oliver, Despres, Clément, Gandhi, Neha S., Hackenberger, Christian P. R., Landrieu, Isabelle, Smet-Nocca, Caroline
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249575/
https://ncbi.nlm.nih.gov/pubmed/34220449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2021.661368
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