Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble intraneuronal fibrils within Alzheimer’s disease (AD) brains. In recent years, other posttranslational modifications (PTMs) have been highlighted...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Front Mol Neurosci
Hoofdauteurs: Cantrelle, François-Xavier, Loyens, Anne, Trivelli, Xavier, Reimann, Oliver, Despres, Clément, Gandhi, Neha S., Hackenberger, Christian P. R., Landrieu, Isabelle, Smet-Nocca, Caroline
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249575/
https://ncbi.nlm.nih.gov/pubmed/34220449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2021.661368
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items