SIRT1 regulates O-GlcNAcylation of tau through OGT

Tau is modified with O-GlcNAcylation extensively in human brain. The O-GlcNAcylation levels of tau are decreased in Alzheimer’s disease (AD) brain. Sirtuin type 1 (SIRT1) is an enzyme that deacetylates proteins including transcriptional factors and associates with neurodegenerative diseases, such as...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Lu, Shu, Yin, Xiaomin, Wang, Jia, Gu, Qun, Huang, Qin, Jin, Nana, Chu, Dandan, Xu, Ziqi, Liu, Fei, Qian, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202539/
https://ncbi.nlm.nih.gov/pubmed/32310828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103062
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