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SIRT1 regulates O-GlcNAcylation of tau through OGT
Tau is modified with O-GlcNAcylation extensively in human brain. The O-GlcNAcylation levels of tau are decreased in Alzheimer’s disease (AD) brain. Sirtuin type 1 (SIRT1) is an enzyme that deacetylates proteins including transcriptional factors and associates with neurodegenerative diseases, such as...
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| Publicado no: | Aging (Albany NY) |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7202539/ https://ncbi.nlm.nih.gov/pubmed/32310828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103062 |
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