Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

[Image: see text] Self-assembly of the microtubule-associated protein tau into neurotoxic oligomers, fibrils, and paired helical filaments, and cell-to-cell spreading of these pathological tau species are critical processes underlying the pathogenesis of Alzheimer’s disease and other tauopathies. Mo...

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Publicat a:ACS Chem Biol
Autors principals: Despres, Clément, Di, Jing, Cantrelle, François-Xavier, Li, Zizheng, Huvent, Isabelle, Chambraud, Béatrice, Zhao, Jing, Chen, Jianle, Chen, Shiguo, Lippens, Guy, Zhang, Fuming, Linhardt, Robert, Wang, Chunyu, Klärner, Frank-Gerrit, Schrader, Thomas, Landrieu, Isabelle, Bitan, Gal, Smet-Nocca, Caroline
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636790/
https://ncbi.nlm.nih.gov/pubmed/31046227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00325
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