Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication

Implicated in numerous human diseases, intrinsically disordered proteins (IDPs) are dynamic ensembles of interconverting conformers that often contain many proline residues. Whether and how proline conformation regulates the functional aspects of IDPs remains an open question, however. Here, we stud...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Dujardin, Marie, Madan, Vanesa, Gandhi, Neha S., Cantrelle, François-Xavier, Launay, Hélène, Huvent, Isabelle, Bartenschlager, Ralf, Lippens, Guy, Hanoulle, Xavier
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721930/
https://ncbi.nlm.nih.gov/pubmed/31315928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009537
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