Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication

Implicated in numerous human diseases, intrinsically disordered proteins (IDPs) are dynamic ensembles of interconverting conformers that often contain many proline residues. Whether and how proline conformation regulates the functional aspects of IDPs remains an open question, however. Here, we stud...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Dujardin, Marie, Madan, Vanesa, Gandhi, Neha S., Cantrelle, François-Xavier, Launay, Hélène, Huvent, Isabelle, Bartenschlager, Ralf, Lippens, Guy, Hanoulle, Xavier
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2019
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721930/
https://ncbi.nlm.nih.gov/pubmed/31315928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009537
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