A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and its interaction with the human chaperone cyclophilin A are both targets for highly potent and promising antiviral drugs that are in the late stages of clinical development. Despite its high interest in regards to the development of drugs to...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dujardin, Marie, Madan, Vanesa, Montserret, Roland, Ahuja, Puneet, Huvent, Isabelle, Launay, Helene, Leroy, Arnaud, Bartenschlager, Ralf, Penin, François, Lippens, Guy, Hanoulle, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521034/
https://ncbi.nlm.nih.gov/pubmed/26085105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644419
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