A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and its interaction with the human chaperone cyclophilin A are both targets for highly potent and promising antiviral drugs that are in the late stages of clinical development. Despite its high interest in regards to the development of drugs to...

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Vydáno v:J Biol Chem
Hlavní autoři: Dujardin, Marie, Madan, Vanesa, Montserret, Roland, Ahuja, Puneet, Huvent, Isabelle, Launay, Helene, Leroy, Arnaud, Bartenschlager, Ralf, Penin, François, Lippens, Guy, Hanoulle, Xavier
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521034/
https://ncbi.nlm.nih.gov/pubmed/26085105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644419
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