Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication

Implicated in numerous human diseases, intrinsically disordered proteins (IDPs) are dynamic ensembles of interconverting conformers that often contain many proline residues. Whether and how proline conformation regulates the functional aspects of IDPs remains an open question, however. Here, we stud...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Dujardin, Marie, Madan, Vanesa, Gandhi, Neha S., Cantrelle, François-Xavier, Launay, Hélène, Huvent, Isabelle, Bartenschlager, Ralf, Lippens, Guy, Hanoulle, Xavier
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721930/
https://ncbi.nlm.nih.gov/pubmed/31315928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009537
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