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Stereospecific Formation of Interstrand Carbinolamine DNA Crosslinks by Crotonaldehyde- and Acetaldehyde-Derived α-CH(3)-γ-OH-1,N(2)-Propano-2’-deoxyguanosine Adducts in the 5′-CpG-3′ Sequence

The crotonaldehyde- and acetaldehyde-derived R- and S-α-CH(3)-γ-OH-1,N(2)-propanodeoxyguanosine adducts were monitored in single-stranded and duplex oligodeoxynucleotides using NMR spectroscopy. In both instances the cis and trans diastereomers of the α-CH(3) and γ-OH groups underwent slow exchange,...

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Bibliografski detalji
Glavni autori: Cho, Young-Jin, Wang, Hao, Kozekov, Ivan D., Kurtz, Andrew J., Jacob, Jaison, Voehler, Markus, Smith, Jarrod, Harris, Thomas M., Lloyd, R. Stephen, Rizzo, Carmelo J., Stone, Michael P.
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631444/
https://ncbi.nlm.nih.gov/pubmed/16485895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx050239z
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