Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Chronic obstructive pulmonary disease (COPD), which comprises emphysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major public health burden with no effective treatment. Emphysema is also associated with pulmonary hypertension, which can progress to right...

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Hlavní autoři: Sussan, Thomas E., Rangasamy, Tirumalai, Blake, David J., Malhotra, Deepti, El-Haddad, Hazim, Bedja, Djahida, Yates, Melinda S., Kombairaju, Ponvijay, Yamamoto, Masayuki, Liby, Karen T., Sporn, Michael B., Gabrielson, Kathleen L., Champion, Hunter C., Tuder, Rubin M., Kensler, Thomas W., Biswal, Shyam
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629210/
https://ncbi.nlm.nih.gov/pubmed/19104057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804333106
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