Nrf2 dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

Sepsis induced lethality is characterized by amplified host innate immune response. Nrf2, a bZIP transcription factor regulates a battery of cellular antioxidative genes and maintains cellular redox homeostasis. This study demonstrates that increasing Nrf2 activity by a potent small molecule activat...

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Detalhes bibliográficos
Main Authors: Thimmulappa, Rajesh K., Scollick, Catherine, Traore, Kassim, Yates, Melinda, Trush, Michael A., Liby, Karen T., Sporn, Michael B., Yamamoto, Masayuki, Kensler, Thomas W., Biswal, Shyam
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293275/
https://ncbi.nlm.nih.gov/pubmed/17097057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.10.102
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