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Nrf2 dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
Sepsis induced lethality is characterized by amplified host innate immune response. Nrf2, a bZIP transcription factor regulates a battery of cellular antioxidative genes and maintains cellular redox homeostasis. This study demonstrates that increasing Nrf2 activity by a potent small molecule activat...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2293275/ https://ncbi.nlm.nih.gov/pubmed/17097057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.10.102 |
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