Preclinical Evaluation of Targeting the Nrf2 Pathway by Triterpenoids (CDDO-Im and CDDO-Me) for Protection from LPS-Induced Inflammatory Response and Reactive Oxygen Species in Human Peripheral Blood Mononuclear Cells and Neutrophils

Sepsis is characterized by an inappropriate host immune-inflammatory response and sustained oxidative damage. Nrf2, a bZIP oxidant-responsive transcription factor, regulates a battery of cytoprotective genes including antioxidants and maintains cellular redox homeostasis. Mouse studies have demonstr...

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Main Authors: THIMMULAPPA, RAJESH K., FUCHS, RALPH J., MALHOTRA, DEEPTI, SCOLLICK, CATHERINE, TRAORE, KASSIM, BREAM, JAY H., TRUSH, MICHAEL A., LIBY, KAREN T., SPORN, MICHAEL B., KENSLER, THOMAS W., BISWAL, SHYAM
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396226/
https://ncbi.nlm.nih.gov/pubmed/17822364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2007.1745
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