p120 Catenin Recruits Cadherins to γ-Secretase and Inhibits Production of Aβ Peptide

The γ-secretase complex cleaves many transmembrane proteins, including amyloid precursor protein, EphB and ErbB tyrosine kinase receptors, Notch1 receptors, and adhesion factors. Presenilin 1, the catalytic subunit of γ-secretase, associates with the cadherin/catenin cell-cell adhesion/communication...

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Bibliografske podrobnosti
Main Authors: Kouchi, Zen, Barthet, Gael, Serban, Geo, Georgakopoulos, Anastasios, Shioi, Junichi, Robakis, Nikolaos K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Enzyme Catalysis and Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629097/
https://ncbi.nlm.nih.gov/pubmed/19008223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806250200
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