Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling

Large granular lymphocyte (LGL) leukemia is commonly associated with poor hematopoiesis. The first case of pulmonary artery hypertension (PAH) was observed in a 57-year-old woman with natural killer (NK)–LGL leukemia and transfusion-dependent anemia. Using a genetic approach, we demonstrated that ki...

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Hlavní autoři: Epling-Burnette, P. K., Sokol, Lubomir, Chen, Xianhong, Bai, Fanqi, Zhou, Junmin, Blaskovich, Michelle A., Zou, JianXiang, Painter, Jeffrey S., Edwards, Todd D., Moscinski, Lynn, Yoder, Jeffrey A., Djeu, Julie Y., Sebti, Said, Loughran, Thomas P., Wei, Sheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597136/
https://ncbi.nlm.nih.gov/pubmed/18791165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-136382
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