Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling

Large granular lymphocyte (LGL) leukemia is commonly associated with poor hematopoiesis. The first case of pulmonary artery hypertension (PAH) was observed in a 57-year-old woman with natural killer (NK)–LGL leukemia and transfusion-dependent anemia. Using a genetic approach, we demonstrated that ki...

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Detalhes bibliográficos
Main Authors: Epling-Burnette, P. K., Sokol, Lubomir, Chen, Xianhong, Bai, Fanqi, Zhou, Junmin, Blaskovich, Michelle A., Zou, JianXiang, Painter, Jeffrey S., Edwards, Todd D., Moscinski, Lynn, Yoder, Jeffrey A., Djeu, Julie Y., Sebti, Said, Loughran, Thomas P., Wei, Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597136/
https://ncbi.nlm.nih.gov/pubmed/18791165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-136382
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