A critical role for DAP10 and DAP12 in CD8(+) T cell–mediated tissue damage in large granular lymphocyte leukemia

Large granular lymphocyte (LGL) leukemia, or LGLL, is characterized by increased numbers of circulating clonal LGL cells in association with neutropenia, anemia, rheumatoid arthritis, and pulmonary artery hypertension (PAH). Emerging evidence suggests that LGLL cells with a CD8(+)CD28(null) phenotyp...

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Autori principali: Chen, Xianghong, Bai, Fanqi, Sokol, Lubomir, Zhou, Junmin, Ren, Amy, Painter, Jeffrey S., Liu, Jinhong, Sallman, David A., Chen, Y. Ann, Yoder, Jeffrey A., Djeu, Julie Y., Loughran, Thomas P., Epling-Burnette, Pearlie K., Wei, Sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665892/
https://ncbi.nlm.nih.gov/pubmed/19075187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-168245
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