Tipifarnib-mediated suppression of T-bet-dependent signaling pathways

Large granular lymphocyte (LGL) leukemia is a chronic lymphoproliferative disease in which T-bet [T-box transcription factor 21 gene (tbx21)] overexpression may play a pathogenic role. T-bet orchestrates the differentiation of mature peripheral T-cells into interferon-γ (IFN-γ) and tumor necrosis fa...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Immunol Immunother
Main Authors: Bai, Fanqi, Villagra, Alejandro V., Zou, JianXiang, Painter, Jeffrey S., Connolly, Kirby, Blaskovich, Michelle A., Sokol, Lubomir, Sebti, Said, Djeu, Julie Y., Loughran, Thomas P., Wei, Sheng, Sotomayor, Eduardo, Epling-Burnette, Pearlie
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2011
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612510/
https://ncbi.nlm.nih.gov/pubmed/21983879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1109-0
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