Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling

Large granular lymphocyte (LGL) leukemia is commonly associated with poor hematopoiesis. The first case of pulmonary artery hypertension (PAH) was observed in a 57-year-old woman with natural killer (NK)–LGL leukemia and transfusion-dependent anemia. Using a genetic approach, we demonstrated that ki...

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Autors principals: Epling-Burnette, P. K., Sokol, Lubomir, Chen, Xianhong, Bai, Fanqi, Zhou, Junmin, Blaskovich, Michelle A., Zou, JianXiang, Painter, Jeffrey S., Edwards, Todd D., Moscinski, Lynn, Yoder, Jeffrey A., Djeu, Julie Y., Sebti, Said, Loughran, Thomas P., Wei, Sheng
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597136/
https://ncbi.nlm.nih.gov/pubmed/18791165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-136382
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