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Total Synthesis and Evaluation of [Ψ[CH(2)NH]Tpg(4)]Vancomycin Aglycon: Reengineering Vancomycin for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding
An effective synthesis of [Ψ[CH(2)NH]Tpg(4)]vancomycin aglycon (5) is detailed in which the residue 4 amide carbonyl of vancomycin aglycon has been replaced with a methylene. This removal of a single atom was conducted to enhance binding to D-Ala-D-Lac countering resistance endowed to bacteria that...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586002/ https://ncbi.nlm.nih.gov/pubmed/16506767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0572912 |
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