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Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein

As part of the mammalian cell innate immune response, the double-stranded RNA activated protein kinase PKR phosphorylates the translation initiation factor eIF2α to inhibit protein synthesis and thus block viral replication. Poxviruses including vaccinia and smallpox viruses express PKR inhibitors s...

詳細記述

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書誌詳細
主要な著者: Seo, Eun Joo, Liu, Furong, Kawagishi-Kobayashi, Makiko, Ung, Tekly L., Cao, Chune, Dar, Arvin C., Sicheri, Frank, Dever, Thomas E.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579349/
https://ncbi.nlm.nih.gov/pubmed/18971339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805524105
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