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Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR
The protein kinase PKR (dsRNA-dependent protein kinase) phosphorylates the eukaryotic translation initiation factor eIF2α to downregulate protein synthesis in virus-infected cells. Two double-stranded RNA binding domains (dsRBDs) in the N-terminal half of PKR are thought to bind the activator double...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125533/ https://ncbi.nlm.nih.gov/pubmed/11447114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.14.3728 |
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