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Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR

The protein kinase PKR (dsRNA-dependent protein kinase) phosphorylates the eukaryotic translation initiation factor eIF2α to downregulate protein synthesis in virus-infected cells. Two double-stranded RNA binding domains (dsRBDs) in the N-terminal half of PKR are thought to bind the activator double...

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Bibliografiske detaljer
Main Authors: Ung, Tekly L., Cao, Chune, Lu, Jianming, Ozato, Keiko, Dever, Thomas E.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC125533/
https://ncbi.nlm.nih.gov/pubmed/11447114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.14.3728
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