Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR

The protein kinase PKR (dsRNA-dependent protein kinase) phosphorylates the eukaryotic translation initiation factor eIF2α to downregulate protein synthesis in virus-infected cells. Two double-stranded RNA binding domains (dsRBDs) in the N-terminal half of PKR are thought to bind the activator double...

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Pubblicato in:	EMBO J
Autori principali:	Ung, Tekly L., Cao, Chune, Lu, Jianming, Ozato, Keiko, Dever, Thomas E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125533/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447114/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.14.3728
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