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Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibition
Responding to viral infection, the interferon-induced, double-stranded RNA (dsRNA)–activated protein kinase PKR phosphorylates translation initiation factor eIF2α to inhibit cellular and viral protein synthesis. To overcome this host defense mechanism, many poxviruses express the protein E3L, contai...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3895273/ https://ncbi.nlm.nih.gov/pubmed/24335187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.042341.113 |
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