A PKR-like eukaryotic initiation factor 2α kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains

The double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is induced as part of the IFN response in mammals and acts to shut down protein synthesis by the phosphorylation of eukaryotic initiation factor 2α (eIF2α). In fish, a PKR-like kinase activity has been detected, but the enzyme responsibl...

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Detalhes bibliográficos
Main Authors: Rothenburg, Stefan, Deigendesch, Nikolaus, Dittmar, Katharina, Koch-Nolte, Friedrich, Haag, Friedrich, Lowenhaupt, Ky, Rich, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC547857/
https://ncbi.nlm.nih.gov/pubmed/15659550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408714102
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