PKR and GCN2 Kinases and Guanine Nucleotide Exchange Factor Eukaryotic Translation Initiation Factor 2B (eIF2B) Recognize Overlapping Surfaces on eIF2α

Four stress-responsive protein kinases, including GCN2 and PKR, phosphorylate eukaryotic translation initiation factor 2α (eIF2α) on Ser51 to regulate general and gene-specific protein synthesis. Phosphorylated eIF2 is an inhibitor of its guanine nucleotide exchange factor, eIF2B. Mutations that blo...

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Detalhes bibliográficos
Main Authors: Dey, Madhusudan, Trieselmann, Bruce, Locke, Emily G., Lu, Jingfang, Cao, Chune, Dar, Arvin C., Krishnamoorthy, Thanuja, Dong, Jinsheng, Sicheri, Frank, Dever, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069625/
https://ncbi.nlm.nih.gov/pubmed/15798194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.8.3063-3075.2005
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