PKR and GCN2 Kinases and Guanine Nucleotide Exchange Factor Eukaryotic Translation Initiation Factor 2B (eIF2B) Recognize Overlapping Surfaces on eIF2α

Eitemau Tebyg

• Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation
  gan: Krishnamoorthy, Thanuja, et al.
  Cyhoeddwyd: (2001)
• Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2α and eIF2Bα: implications for aIF2B function and eIF2B regulation
  gan: Dev, Kamal, et al.
  Cyhoeddwyd: (2009)
• The β/Gcd7 Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2B), a Guanine Nucleotide Exchange Factor, Is Crucial for Binding eIF2 In Vivo
  gan: Dev, Kamal, et al.
  Cyhoeddwyd: (2010)
• Association of GCN1–GCN20 regulatory complex with the N-terminus of eIF2α kinase GCN2 is required for GCN2 activation
  gan: Garcia-Barrio, Minerva, et al.
  Cyhoeddwyd: (2000)
• HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2
  gan: Peidis, Philippos, et al.
  Cyhoeddwyd: (2010)