Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2α and eIF2Bα: implications for aIF2B function and eIF2B regulation

Translation initiation is down-regulated in eukaryotes by phosphorylation of the α subunit of eIF2, which inhibits its guanine nucleotide exchange factor eIF2B. The N-terminal S1 domain of phosphorylated eIF2α interacts with a subcomplex of eIF2B formed by the three regulatory subunits, α/GCN3, β/GC...

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Autores principales: Dev, Kamal, Santangelo, Thomas J., Rothenburg, Stefan, Neculai, Dante, Dey, Madhusudan, Sicheri, Frank, Dever, Thomas E., Reeve, John N., Hinnebusch, Alan G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937263/
https://ncbi.nlm.nih.gov/pubmed/19616556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.07.030
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