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Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2α and eIF2Bα: implications for aIF2B function and eIF2B regulation
Translation initiation is down-regulated in eukaryotes by phosphorylation of the α subunit of eIF2, which inhibits its guanine nucleotide exchange factor eIF2B. The N-terminal S1 domain of phosphorylated eIF2α interacts with a subcomplex of eIF2B formed by the three regulatory subunits, α/GCN3, β/GC...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2937263/ https://ncbi.nlm.nih.gov/pubmed/19616556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.07.030 |
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