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Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein
As part of the mammalian cell innate immune response, the double-stranded RNA activated protein kinase PKR phosphorylates the translation initiation factor eIF2α to inhibit protein synthesis and thus block viral replication. Poxviruses including vaccinia and smallpox viruses express PKR inhibitors s...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579349/ https://ncbi.nlm.nih.gov/pubmed/18971339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805524105 |
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