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Sarcospan reduces dystrophic pathology: stabilization of the utrophin–glycoprotein complex

Mutations in the dystrophin gene cause Duchenne muscular dystrophy and result in the loss of dystrophin and the entire dystrophin–glycoprotein complex (DGC) from the sarcolemma. We show that sarcospan (SSPN), a unique tetraspanin-like component of the DGC, ameliorates muscular dystrophy in dystrophi...

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Bibliografiske detaljer
Main Authors: Peter, Angela K., Marshall, Jamie L., Crosbie, Rachelle H.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575773/
https://ncbi.nlm.nih.gov/pubmed/18981229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200808027
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