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Sarcospan reduces dystrophic pathology: stabilization of the utrophin–glycoprotein complex

Mutations in the dystrophin gene cause Duchenne muscular dystrophy and result in the loss of dystrophin and the entire dystrophin–glycoprotein complex (DGC) from the sarcolemma. We show that sarcospan (SSPN), a unique tetraspanin-like component of the DGC, ameliorates muscular dystrophy in dystrophi...

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Bibliographic Details
Main Authors: Peter, Angela K., Marshall, Jamie L., Crosbie, Rachelle H.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575773/
https://ncbi.nlm.nih.gov/pubmed/18981229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200808027
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