Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice

Sarcospan (SSPN) is a core component of the major adhesion complexes in skeletal muscle, the dystrophin– and utrophin (Utr)–glycoprotein complexes (DGC and UGC). We performed a rigorous analysis of SSPN-null mice and discovered that loss of SSPN decreased DGC and UGC abundance, leading to impaired l...

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Main Authors: Marshall, Jamie L., Chou, Eric, Oh, Jennifer, Kwok, Allan, Burkin, Dean J., Crosbie-Watson, Rachelle H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459462/
https://ncbi.nlm.nih.gov/pubmed/22798625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds271
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