Loss of sarcospan exacerbates pathology in mdx mice, but does not affect utrophin amelioration of disease

The dystrophin–glycoprotein complex (DGC) is a membrane adhesion complex that provides structural stability at the sarcolemma by linking the myocyte’s internal cytoskeleton and external extracellular matrix. In Duchenne muscular dystrophy (DMD), the absence of dystrophin leads to the loss of the DGC...

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發表在:Hum Mol Genet
Main Authors: Gibbs, Elizabeth M, McCourt, Jackie L, Shin, Kara M, Hammond, Katherine G, Marshall, Jamie L, Crosbie, Rachelle H
格式: Artigo
語言:Inglês
出版: Oxford University Press 2021
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General Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091037/
https://ncbi.nlm.nih.gov/pubmed/33432327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa264
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