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Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration
Utrophin is normally confined to the neuromuscular junction (NMJ) in adult muscle and partially compensates for the loss of dystrophin in mdx mice. We show that Akt signaling and utrophin levels were diminished in sarcospan (SSPN)-deficient muscle. By creating several transgenic and knockout mice, w...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384411/ https://ncbi.nlm.nih.gov/pubmed/22734004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110032 |
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