Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration

Utrophin is normally confined to the neuromuscular junction (NMJ) in adult muscle and partially compensates for the loss of dystrophin in mdx mice. We show that Akt signaling and utrophin levels were diminished in sarcospan (SSPN)-deficient muscle. By creating several transgenic and knockout mice, w...

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Main Authors: Marshall, Jamie L., Holmberg, Johan, Chou, Eric, Ocampo, Amber C., Oh, Jennifer, Lee, Joy, Peter, Angela K., Martin, Paul T., Crosbie-Watson, Rachelle H.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384411/
https://ncbi.nlm.nih.gov/pubmed/22734004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110032
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