Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration

Utrophin is normally confined to the neuromuscular junction (NMJ) in adult muscle and partially compensates for the loss of dystrophin in mdx mice. We show that Akt signaling and utrophin levels were diminished in sarcospan (SSPN)-deficient muscle. By creating several transgenic and knockout mice, w...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Marshall, Jamie L., Holmberg, Johan, Chou, Eric, Ocampo, Amber C., Oh, Jennifer, Lee, Joy, Peter, Angela K., Martin, Paul T., Crosbie-Watson, Rachelle H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2012
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384411/
https://ncbi.nlm.nih.gov/pubmed/22734004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110032
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