Loss of sarcospan exacerbates pathology in mdx mice, but does not affect utrophin amelioration of disease

The dystrophin–glycoprotein complex (DGC) is a membrane adhesion complex that provides structural stability at the sarcolemma by linking the myocyte’s internal cytoskeleton and external extracellular matrix. In Duchenne muscular dystrophy (DMD), the absence of dystrophin leads to the loss of the DGC...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Hum Mol Genet
Main Authors: Gibbs, Elizabeth M, McCourt, Jackie L, Shin, Kara M, Hammond, Katherine G, Marshall, Jamie L, Crosbie, Rachelle H
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
General Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091037/
https://ncbi.nlm.nih.gov/pubmed/33432327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa264
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