Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

Neural precursor cells (NPCs) differentiate into neurons, astrocytes, and oligodendrocytes in response to intrinsic and extrinsic changes. Notch signals maintain undifferentiated NPCs, but the mechanisms underlying the neuronal differentiation are largely unknown. We show that SIRT1, an NAD(+)-depen...

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Bibliografiska uppgifter
Huvudupphovsmän: Hisahara, Shin, Chiba, Susumu, Matsumoto, Hiroyuki, Tanno, Masaya, Yagi, Hideshi, Shimohama, Shun, Sato, Makoto, Horio, Yoshiyuki
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563076/
https://ncbi.nlm.nih.gov/pubmed/18829436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800612105
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