Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

Neural precursor cells (NPCs) differentiate into neurons, astrocytes, and oligodendrocytes in response to intrinsic and extrinsic changes. Notch signals maintain undifferentiated NPCs, but the mechanisms underlying the neuronal differentiation are largely unknown. We show that SIRT1, an NAD(+)-depen...

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Main Authors: Hisahara, Shin, Chiba, Susumu, Matsumoto, Hiroyuki, Tanno, Masaya, Yagi, Hideshi, Shimohama, Shun, Sato, Makoto, Horio, Yoshiyuki
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563076/
https://ncbi.nlm.nih.gov/pubmed/18829436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800612105
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