Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

Neural precursor cells (NPCs) differentiate into neurons, astrocytes, and oligodendrocytes in response to intrinsic and extrinsic changes. Notch signals maintain undifferentiated NPCs, but the mechanisms underlying the neuronal differentiation are largely unknown. We show that SIRT1, an NAD(+)-depen...

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書誌詳細
主要な著者: Hisahara, Shin, Chiba, Susumu, Matsumoto, Hiroyuki, Tanno, Masaya, Yagi, Hideshi, Shimohama, Shun, Sato, Makoto, Horio, Yoshiyuki
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2008
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563076/
https://ncbi.nlm.nih.gov/pubmed/18829436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800612105
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