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Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
Neural precursor cells (NPCs) differentiate into neurons, astrocytes, and oligodendrocytes in response to intrinsic and extrinsic changes. Notch signals maintain undifferentiated NPCs, but the mechanisms underlying the neuronal differentiation are largely unknown. We show that SIRT1, an NAD(+)-depen...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2563076/ https://ncbi.nlm.nih.gov/pubmed/18829436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800612105 |
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