Induced Fit Conformational Changes of a “Reversed Amidine” Heterocycle: Optimized Interactions in a DNA Minor Groove Complex

To better understand the molecular basis for recognition of the DNA minor groove by heterocyclic cations, a series of “reversed amidine” substituted heterocycles has been prepared. Amidine derivatives for targeting the minor groove have the amidine carbon linked to a central heterocyclic system whil...

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Hlavní autoři: Munde, Manoj, Lee, Michael, Neidle, Stephen, Arafa, Reem, Boykin, David W., Liu, Yang, Bailly, Christian, Wilson, W. David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547086/
https://ncbi.nlm.nih.gov/pubmed/17425312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja069003n
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