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Molecular Defects Caused by Temperature-Sensitive Mutations in Semliki Forest Virus nsP1

Alphavirus replicase protein nsP1 has multiple functions during viral RNA synthesis. It catalyzes methyltransferase and guanylyltransferase activities needed in viral mRNA capping, attaches the viral replication complex to cytoplasmic membranes, and is required for minus-strand RNA synthesis. Two te...

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Bibliografiska uppgifter
Huvudupphovsmän: Lulla, Valeria, Sawicki, Dorothea L., Sawicki, Stanley G., Lulla, Aleksei, Merits, Andres, Ahola, Tero
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546902/
https://ncbi.nlm.nih.gov/pubmed/18596091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00711-08
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