Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown. We hypothesized that the transcriptional regulator of the stress response, heat sho...

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Detaylı Bibliyografya
Asıl Yazarlar: Steele, Andrew D., Hutter, Gregor, Jackson, Walker S., Heppner, Frank L., Borkowski, Andrew W., King, Oliver D., Raymond, Gregory J., Aguzzi, Adriano, Lindquist, Susan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533240/
https://ncbi.nlm.nih.gov/pubmed/18757733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806319105
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