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Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases
In man, mutations in different regions of the prion protein (PrP) are associated with infectious neurodegenerative diseases that have remarkably different clinical signs and neuropathological lesions. To explore the roots of this phenomenon, we created a knock-in mouse model carrying the mutation as...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3767526/ https://ncbi.nlm.nih.gov/pubmed/23959875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312006110 |
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