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Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases

In man, mutations in different regions of the prion protein (PrP) are associated with infectious neurodegenerative diseases that have remarkably different clinical signs and neuropathological lesions. To explore the roots of this phenomenon, we created a knock-in mouse model carrying the mutation as...

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Detalhes bibliográficos
Main Authors: Jackson, Walker S., Borkowski, Andrew W., Watson, Nicki E., King, Oliver D., Faas, Henryk, Jasanoff, Alan, Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767526/
https://ncbi.nlm.nih.gov/pubmed/23959875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312006110
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