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Spontaneous generation of prion infectivity in fatal familial insomnia knock-in mice
A crucial tenet of the prion hypothesis is that misfolding of the prion protein (PrP) induced by mutations associated with familial prion disease is, in an otherwise normal mammalian brain, sufficient to generate the infectious agent. Yet this has never been demonstrated. We engineered knock-in mice...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775465/ https://ncbi.nlm.nih.gov/pubmed/19709627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.07.026 |
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