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Spontaneous generation of prion infectivity in fatal familial insomnia knock-in mice
A crucial tenet of the prion hypothesis is that misfolding of the prion protein (PrP) induced by mutations associated with familial prion disease is, in an otherwise normal mammalian brain, sufficient to generate the infectious agent. Yet this has never been demonstrated. We engineered knock-in mice...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775465/ https://ncbi.nlm.nih.gov/pubmed/19709627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.07.026 |
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