Diminishing Apoptosis by Deletion of Bax or Overexpression of Bcl-2 Does Not Protect against Infectious Prion Toxicity In Vivo

B-cell lymphoma protein 2 (Bcl-2) and Bcl-2-associated X protein (Bax), key antiapoptotic and proapoptotic proteins, respectively, have important roles in acute and chronic models of neurologic disease. Several studies have implicated Bax and Bcl-2 in mediating neurotoxicity in prion diseases. To de...

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Detalhes bibliográficos
Main Authors: Steele, Andrew D., King, Oliver D., Jackson, Walker S., Hetz, Claudio A., Borkowski, Andrew W., Thielen, Peter, Wollmann, Robert, Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588055/
https://ncbi.nlm.nih.gov/pubmed/18032675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3290-07.2007
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