Dominant-Negative Inhibition of Prion Formation Diminished by Deletion Mutagenesis of the Prion Protein

Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. T...

Description complète

Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Zulianello, Laurence, Kaneko, Kiyotoshi, Scott, Michael, Erpel, Susanne, Han, Dong, Cohen, Fred E., Prusiner, Stanley B.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Structure and Assembly
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111952/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756050/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4351-4360.2000
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!