Dominant-Negative Inhibition of Prion Formation Diminished by Deletion Mutagenesis of the Prion Protein

Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. T...

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Bibliographic Details
Main Authors: Zulianello, Laurence, Kaneko, Kiyotoshi, Scott, Michael, Erpel, Susanne, Han, Dong, Cohen, Fred E., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC111952/
https://ncbi.nlm.nih.gov/pubmed/10756050
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