Potent inhibition of scrapie prion replication in cultured cells by bis-acridines
Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency...
Sábháilte in:
| Foilsithe in: | Proc Natl Acad Sci U S A |
|---|---|
| Príomhchruthaitheoirí: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe / Cruthaithe: |
National Academy of Sciences
2003
|
| Ábhair: | |
| Rochtain ar líne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12626750/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2627988100 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
|