Potent inhibition of scrapie prion replication in cultured cells by bis-acridines

Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: May, Barnaby C. H., Fafarman, Aaron T., Hong, Septima B., Rogers, Michael, Deady, Leslie W., Prusiner, Stanley B., Cohen, Fred E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC152307/
https://ncbi.nlm.nih.gov/pubmed/12626750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2627988100
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi